According to local officials, the fires in America's second-largest city have already burned some 1,500 buildings and forced more than 130,000 people from their homes.
Strong gusts of wind carried flames and embers hundreds of metres, sparking new fires faster than firefighters could put them out.
Many evacuations took place in the Pacific Palisades area, where many celebrities live, and in parts of Santa Monica and Altadena.
On Wednesday evening, a fire broke out in Ronjon Canyon in the heart of Hollywood, close to historic landmarks such as Grauman's Chinese Theatre, the Avenue of the Stars and the El Capitan Theatre, as well as the AFP offices. As a result of the wildfire, traffic jams have formed on the streets of Hollywood, making it difficult for residents to leave the city.
Janisse Quinones, general manager of the Los Angeles Department of Water and Power, appealed to residents to conserve water after hydrants in Pacific Palisades ran out of water.
Los Angeles City Council President Marqueece Harris-Dawson assessed at a press conference that the current fires are among the ‘most devastating and horrific’ the city has seen.
The White House has given notice that US President Joe Biden has cancelled a trip to Italy in the wake of the elements to focus on efforts to fight the fires in California.