South Africans are being urged to mark the former president and anti-apartheid leader's 67 years of public service with 67 minutes of charitable acts.
Mr Mandela, who is in critical but stable condition with a recurring lung infection, entered hospital on 8 June.
Mr Mandela's daughter, Zindzi, said on Wednesday he had made "dramatic progress", and that she had found him watching television with headphones on and communicating with his eyes and hands when she visited him this week.
Mr Mandela's birthday is also Nelson Mandela International Day, a day declared by the UN as a way to recognise the Nobel Prize winner's contribution to reconciliation.
The former statesman is revered across the world for his role in ending apartheid in South Africa. He went on to become the first black president in the country's first multi-racial elections in 1994.
Mr Mandela's third wife, Graca Machel, said last Friday that she was "less anxious" about his health than before and that he was continuing to respond well to treatment.
Thursday also is the 15th anniversary of the couple's marriage.
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