The 16-strong team will take a flight from Vilnius to Krasnoyarsk and will then travel for several more hours to Igarka.
Arnoldas Fokas, who leads the expedition to Siberia for the eighth time, says that they chose Igarka because the town had the biggest concentration of Lithuanian deportees.
Over 8,000 Lithuanians were deported to Igarka in 1948 alone.
There are three Lithuanian cemeteries in Igarka. One of the cemeteries has around 1,000 graves, many of which still have Lithuanian crosses on them, the President's Office, which supports the initiative, said.
Fokas says that a considerable number of the remains of Lithuanian deportees were brought back to Lithuania between 1989 and 1990, but a large part of graves still remain in Igarka.
The Mission Siberia project was launched in 2005.